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326 Research has demonstrated that autophagy promotes longevity by mitigating the deleterious effects of cellular senescence and accumulation of damaged biomolecules, which are hallmarks of neurodegenerative diseases

And I dont think thats because cholesterol causes heart disease, but I think its because its a reflection of your overall metabolism being more slow in terms of actually using up the cholesterol

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When the production of ROS exceeds the counteracting mechanisms of the antioxidant system, oxidative stress will occur, resulting in oxidative damage to proteins, nucleic acids and lipids, affecting the normal functioning of the body and inducing the occurrence of various diseases such as NDs 22 , 24